Leptin

Leptin         In the mid 1980s Amgen bought the rights to study the leptin molecule, the key governor of fat stores. It was thought to have peachy probable for treating obesity. The botheration surrounding leptin was ground on several studies that showed that when leptin was injected into mice and rats with genetically prove obesity, it caused them to decrease food intake and drop to a reflexion freight with no side effects. The naughtyer the leptin levels in the source serum, the more(prenominal) pronounced the effect was. There beted to be great potential for therapeutic uses of leptin. A setback occurred with the finding that closely commode with non-genetically based obesity had higher than normal levels of leptin in their blood, which would seem to be in conflict with the weight-reducing effect of high leptin in the rodent studies. It was theorized that grave people might execute disgustful to their sustain leptin in a way akin to obe se people who develop diabetes because they become resistant to their own insulin. concomitant clinical trials where leptin was administered to obese people showed no noteworthy weight loss. It was thought that leptin was not crossing the blood-brain barrier in mystify to affect its target organ, the brain. Leptin Regulation:         Leptin is a 16 kDa protein express exclusively in adipose tissue.

It is a endocrine that communicates the term of energy stores to the hypothalamus. Higher leptin levels correlate with energy intake and pocket-sized leptin levels correlate with energy saving (2-4; 12-15). Low leptin levels ar found in rodents with the leptin gene (ob gene) knocked out and in people with mut! ations in the ob gene (14).         Several factors contribute to leptin levels. The nearly primary(prenominal) contribution is the amount of body fat, but age, gender, hormones and cytokine levels in appendix have an effect... If you want to get a full essay, ordinate it on our website: OrderEssay.net

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